P38a MAPK underlies muscular dystrophy and myofiberdeaththroughaBax-dependentmechanism
نویسندگان
چکیده
Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, 240 Albert Sabin Way, Cincinnati, OH 45229, USA, Department of Medicine, Section of Cardiology, University of Chicago, 5841 S.Maryland,MC6088,Chicago, IL60637,USA, CardiovascularDivision,King’sCollegeLondon,125ColdharbourLane, London SE5 9NU, UK and Howard Hughes Medical Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, 240 Albert Sabin Way, Cincinnati, OH 45229, USA
منابع مشابه
Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy.
Mutations in LMNA, which encodes nuclear Lamins A and C cause diseases affecting various organs, including the heart. We have determined the effects of an Lmna H222P mutation on signaling pathways involved in the development of cardiomyopathy in a knockin mouse model of autosomal dominant Emery-Dreifuss muscular dystrophy. Analysis of genome-wide expression profiles in hearts using Affymetrix G...
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